Abstract

EFFECT OF GYNANDROPSIS PENTAPHYLLA LEAVES ON MILK INDUCED EOSINOPHILIA AND LEUCOCYTOSIS IN MICE

Ujwala S. Dube* and Sunil A. Nirmal

Abstract

Gynandropsis pentaphylla syn. Cleome pentaphylla, (Capparadiaceae) is commonly known as „Pandharitilvan and Safedhulhul‟. G. pentaphylla is a annual, erect, branched plant Various parts of the plant are reported as rubefacient, counter-irritant, anthelmintic, in neuralgia, headache and otalgia. Terpenes, β-carotene, sterols, fatty acids, flavonoids, glycosides and alkaloids were reported from various part of plant. The seeds are anthelmintic and rubefacient and used internally for expulsion of round worms and externally as counter irritant and in headache. The seeds and leaves of G. pentaphylla have immunosupressent, anthelmintic, antifungal and antimicrobial activity. Objective of present work is to evaluate different extracts of G.pentaphylla for preliminary phytochemical screening and for milk induced eosinophilia and leucocytosis in mice. Different extract shows presence of alkaloids, tannins, flavonoids and Saponins. All the extracts were found to be significantly effective against eosinophilia and leucocytosis in mice. The aqueous and methanolic extracts shows prominent inhibition when compare with standard drug dexamethasone.

Keywords: Gynandropsis pentaphylla, asthma, leucocytosis, milk, eosinophilia.