Abstract

SPECTROPHOTOMETRIC DETERMINATION OF CETIRIZINE DRUG IN BULK AND PHARMACEUTICAL FORMULATIONS

Ritika Manoj Makhijani*, Vighnesh Nalawade and Vasannt Dnyandeo Barhate

Abstract

A new simple, precise, sensitive, accurate and reproducible spectrophotometric method have been developed for determination of cetirizine in pure and dosage forms. Method is based on oxidation of drug with 1, 10phenanthroline producing orange colour chromogen which is measured at 510 nm. Beer’s Law is obeyed in the concentration range of 1.0 – 8.0 μg/ml for the developed method. The molar absorptivity and sandell’s sensivity are found to be 2778 L mol-1 cm-1 and 0.14 μg/cm2 respectively. Different experimental parameter affecting the colour development and stability of coloured products are carefully studied and optimized. The developed method could be successfully applied to pharmaceutical formulations. The result obtained are in good agreement with those obtained using standard method.

Keywords: Cetirizine, spectrophotometric method 1,10 phenonthroline.