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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF BENZOHYDRAZIDE DERIVATIVES LINKING THIENO[3,2- c]PYRIDINE NUCLEUS

N. Sree Lakshmana Rao, Mandava V. Basaveswara Rao* and KRS Prasad

Abstract

The present paper describes the synthesis and antibacterial activity ofthieno [3, 2-c] pyridine-hydrazide–hydrazone derivatives (9a-j) fromreadily accessible starting material Thiophene aldehyde. All the newlysynthesized hydrazone derivatives are characterized by 1H NMR, massand IR data. These compounds were further evaluated for antibacterialactivity against Gram-positive and Gram negative bacteria. Most of thecompounds showed promising anti-bacterial activity.

Keywords: Hydrazones, Thieno[3,2-c]pyridine, 2- Thiophenealdehyde, Antibacterial activity, Synthesis.

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