Abstract

THE PROTECTIVE ROLE OF VIT-C (ASCORBIC ACID) AGAINST SODIUM FLUORIDE (NaF) TOXICITY ON REPRODUCTIVE SYSTEM OF ADULT MALE ALBINO RAT

Shyamal Kanti Das, *Chandan Roy and Sahina Khatun

Abstract

Fluorosis is an endemic public health problem in nearly 22 nations around the world. The present study has been undertaken to show the effect of Sodium fluoride (NaF) on male reproductive system and also to establish the protective role of ascorbic acid (Vitamin C) on this system. vitamin C partially attenuated some male reproductive system dysfunctions in hyperglycemic rats. It has been showed that oxidative stress plays a possible role in the apoptosis of Sertoli cells induced by NaF, and that these effects can be suppressed with vitamin C. In our present study, NaF at a dose of 20mg/kg body weight significantly reduced the body weight, testicular weight and epididymal weight as compared to NaF+Vit-C treated group. Vit-C significantly increased the body weight, testicular weight and epididymal weight at a dose of 20mg/kg body weight as compared to NaF+Vit-C treated group. NaF at a dose of 20mg/kg body weight significantly reduced the sperm count as well as sperm motility as compared to NaF+Vit-C treated group. Vit-C significantly increased the sperm count as well as sperm motility at a dose of 20mg/kg body weight as compared to NaF+Vit-C treated group and NaF treated group respectively.

Keywords: Fluorosis, Sodium fluoride, Ascorbic acid, Male reproductive system, Sertoli cell.