Abstract

DETERMINATION AND ASSAY OF SOME ANTINEOPLASTIC AGENTS IN PURE FORM AND IN THEIR PHARMACEUTICAL PREPARATIONS USING TITRIMETRIC METHOD

*Parulekar G. T.

Abstract

Antineoplastics drugs are the drugs that prevent or inhibit the maturation and proliferation of neoplasms. Antineoplastic agents travel the body and destroy cancer cells. Many of the side effects associated with antineoplastic agents occur because treatment destroys the body's normal cells in addition to cancerous cells. In the present work we have developed a titrimetric method for the determination of some Antineoplastic agents i.e. Capecitabine, Mercaptopurine, Gemcitabine and 5-Fluorouracil in pure form and in their pharmaceutical preparations like Xeloda (Tab.), Purinethol (Tab), Gemzar (Inj) and Adrucil (Inj) by using Nchlorosuccinimide (NCS) reagent in acidic medium. A result shows that the suggested method is accurate, reproducible and precise. It can easily be adopted in an ordinary pharmaceutical laboratory where sophisticated instruments are not available.

Keywords: Antineoplastic agents, titrimetric method, Capecitabine, Mercaptopurine.