Abstract

COMPARATIVE ANALYSIS OF THROMBOLYTIC ACTIVITY OF ETHANOL EXTRACT AND ITS DIFFERENT FRACTIONS OF ANOGEISSUS ACUMINATA LEAVES

Mahmudul Hasan*, Syed Md. Abdul Kader, Md Imdadul Haque, Ebrahim Khan Samrat, Nishat Rahman, Mohammad Ikram Uddin, Md. Golam Sarowar and Jackie Barua

Abstract

This study shows the thrombolytic effect of different ethanol extracts and fractions of the leaves of Anogeissus acuminata by thrombolysis which is also known as thrombolytic therapy, we mean a treatment to dissolve dangerous clots in blood vessels, improve blood flow, and prevent damage to tissues and organs. In this experiment fraction of leaves of A. acuminata, as this is a medicinal plant. These were used in the treatment of thrombolytic therapy because it shows remarkable result in thrombolytic activity. Using an in vitro antithrombotic model, all extracts, fractions, and Streptokinase exhibited significant (P < 0.0001) clot lysis. EEAA extract exhibited highest % of clot lysis 44.14 ± 3.26 (P < 0.0001, P < 0.001). So this plant can further be used in cardiovascular diseases. One of the main causes of multiple cardiovascular diseases is intravascular thrombosis and current agents, which are used for the treatment and prevention of thrombosis but have some serious side effects. Therefore, new antithrombotic and thrombolytic agents are still needed. So this experiment can be referred over the drugs with hazardous side effects.

Keywords: Anogeissus acuminata, extract, leaves, antithrombotic, fraction.