Abstract

PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ANTINOCICEPTIVE ACTIVITY STUDIES WITH METHANOL EXTRACT OF WHOLE PLANTS OF SENNA OBTUSIFOLIA

Sabrina Irin, Md. Shamim Bappy, Lutfun Neesa and Mohammed Rahmatullah*

Abstract

Objective: The objective of the present study was to phytochemically screen and evaluate the antinociceptive potential of methanolic extract of Senna obtusifolia whole plants. Methods: Extract was administered orally at doses of 50-400 mg/kg. Antinociceptive activity was assessed in intraperitoneally injected acetic acid-induced pain model. Results: In acetic acid-induced pain model, the extract reduced the number of abdominal constrictions by 20.0, 40.0, 51.4, and 62.9%, respectively, at doses of 50, 100, 200 and 400 mg/kg. A standard analgesic drug, aspirin (200 and 400 mg/kg) reduced abdominal constrictions by 40.0 and 65.7%, respectively. Conclusion: The extract possesses significant antinociceptive potential.

Keywords: Senna obtusifolia, Fabaceae, antinociceptive, writhing.