Abstract

THE COMPREHENSIVE REVIEW ON SOLID DISPERSION TECHNOLOGY

Pankaj R. Khuspe*, Kishori Kokate, Trushali Mandhare, Kishor Otari and Prashant Katiyar

Abstract

Solid dispersions is drawn attention and interest of researchers for improvement and enhancement the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration. Solid dispersions modify the dissolution properties of the drugs and produce solid, powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage forms. This review highlights on definition, types, method of preparation, characterization advantages and disadvantages of the solid dispersion.

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