Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION PROPERTIES OF BOSENTAN BY INCLUSION COMPLEXATION

Bharathi A.*, G. Bhargavi, Ch. Sri Sailaja and D. Chandra Sekhar Naik

Abstract

The cyclodextrins have a wide range of applications in different areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most common pharmaceutical application of cyclodextrin is to enhance the solubility, stability, safety and bio availability of drug molecules. The major aim of the study was to enhance the solubility and dissolution rate of Bosentan by complexation with Cyclodextrins (β-CD). The solid complexes of bosentan and β-CD were prepared in 1:1 and 1:2 molar ratios by two methods like kneading and co-solvent evaporation. The binary complexes 1:1 molar ratio of kneading method heighted of drug release compared to reaming method of ratios. Further the selected cyclodextrin complexes are designed to formulate dispersible tablet using selected for different concentration of super disintegrate like sodium starch glycol late, dicalcium phosphate by direct compression method. The optimized formulation showed more than 80% drug release with in 1hr.

Keywords: Bosentan, Cyclodextrins, inclusion complexation, solubility enhancement, dissolution rate.