Abstract

GASTRO-PROTECTIVE ACTIVITY OF LEAVES OF MANGIFERA INDICA IN ULCER INDUCED ALBINO RATS

Pratit Kanchan Sahu*, Sujit Kumar Martha and Debasish Pradhan

Abstract

Mangifera indica (Family: Anacardiaceae) is being used in Indian Folk Medicine for the treatment of various diseases including gastric ulcer. In the present study, we investigated the gastro-protective potential of ethanolic & aqueous extracts of Mangifera indica leaves against gastric ulcer induced by several experimental methods. The ethanolic extracts (400 mg/kg) of Mangifera indica leaves significantly reduced the volume of gastric juice, total acidity, free acidity and ulcer index. Thus, our present study results clearly demonstrate that ethanolic extract of Mangifera indica leaves is in possession of good preventive and therapeutic action on the gastric ulcers and supports the traditional uses of the plant.

Keywords: Mangifera indica leaves, Pylorus Ligation, Gastro-protective, Aspirin, Albino rat.