Abstract

FORMULATION AND EVALUATION OF FLOATING MICROSPHERES CONTAINING RABEPRAZOLE

Shakera Sultana* and H. Padmalatha

Abstract

The aim of the present study was to develop floating microspheres containing rabeprazole. Floating microspheres were prepared by solvent evaporation technique by varying the drug polymer ratio. The floating microspheres formulations were then evaluated for their micromeritic properties such as carr‟s index, hausner‟s ratio, density, size and shape, drug incorporation efficiency and buoyancy percentage. In-vitro dissolution studies for all the formulations were performed in 0.1M HCl media, which is the ideal media. From the dissolution studies it was evident that all the formulations showed a better drug release pattern. But the formulation F3 was considered as an optimised formulation because of its desired drug release pattern of up to 98%. The release was sustained as the polymer is increased.

Keywords: Rabeprazole; sustained release; floating microspheres; dissolution.