Abstract

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SUBSTITUTED 1,5-BENZODIAZEPINE DERIVATIVES FOR ITS ANTIDEPRESSANT ACTIVITY IN EXPERIMENTAL ANIMALS

Ranjana Sharma, Amita Tilak, R. N. Thakur, Sudhir Singh Gangwar and Ravindra C. Sutar*

Abstract

The reaction of OPD with acetoacetic acid in presence of heat gives substituted benzimidazoles, which on treatment with substituted aromatic aldehydes undergoes claisen-schmidt condensation to offer chalcones, which on further treatment with OPD gives substituted benzodiazepines (A1-A5) as a result of Michael addition reaction. The purity of the synthesized compounds was checked by TLC and the structure of the synthesized compounds was established using IR, 1H-NMR and elemental analysis. The purified compounds were then screened for their anti-depressant activity using forced swim test model on mice.

Keywords: Anti-depressant, forced swim test, 1,5-BZD, synthesis, chalcones, Michael addition.