Abstract

EVALUATION OF CELASTRUS PANICULATUS IN LEARNING AND MEMORY OF RATS BY T- MAZE TEST

Ranjana Bohra* and Dr. K. K. Maheshwary

Abstract

Present research work was performed to evaluate the effect of Celastrus paniculatus against scopolamine induced dementia in rats. Learning and memory enhancing potentials of the Celastrus paniculatus were compared with donepezil. Memory performance was studied in rats by using T-Maze apparatus. Rats of either sex were divided into six group each group contain six animals. On day 1st, 8th and 15th each animal was tested for learning and memory by using TMaze. Scopolamine group show decline in memory performance while the donepezil group show significant decrease in time which leads to effective learning and memory as compared to other groups. Celastrus paniculatus extract show increase in memory performance as compared to other groups. This shows the memory enhancing activity of aqueous extract of Celastrus paniculatus.

Keywords: Celastrus paniculatus, T-Maze, Donepezil, Scopolamine.