Abstract

WOUND HEALING ACTIVITY OF FLOWER HEAD AQUOUS EXTRACT OF SPHAERANTHUS INDICUS LINN. IN DIABETIC RATS

Rajeev Kumar* and Rajesh Kumar Nema

Abstract

The present work was to assess the wound healing activity of Sphaeranthus Indicus flower head by providing better tissue formation and protection against microbial invasion. Various ointments of extracts in various proportions were prepared and subjected for assessment of wound healing activity in diabetic albino rats (Wister strain). Based on the comparison of wound healing activity of various formulations, the formulation comprising of 300 mg/kg aqueous extract of flower head of sphaeranthus indicus found to be superior to that of control and standard formulation. In addition to greater Hydroxyproline content found in healed wounds, the formulation also showed formation of epidermis, keratinization, connective tissue, vascular tissue and collagen at greater level as compared to control and standard formulation.

Keywords: Sphaeranthus Indicus, Diabetes, Wound healing, Extract, Ointment, Hydroxyproline content, Histopathological Studies, wound contraction, Tensile Strength.