Abstract

CHROMOGENIC-VISIBLE-SPECTROPHOTOMETRIC QUANTIFICATION OF ACOTIAMIDE IN BULK DRUG AND ITS FORMULATION

Imam Pasha S.*, Murali Balaram Varanasi1 and Ibrahim Mohammed

Abstract

Simple, precise, economic and less time consuming visible spectroscopic method for quantification of Acotiamide was developed by using MBTH, Ferric chloride. The absorption maximum of the chromogen was found to be 630 nm. The developed method was obeying Beer Lambert’s law in the range of 10-100 μg/ml concentration. The method has also been statistically evaluated and the results were within the limits. Molar absorptivity, Sand ell’s sensitivity and correlation –co-efficient were found to be 1.4596×1012, 0.107 and 0.997 respectively and the method is free from the interferences of other additives present in the formulation.

Keywords: Acotiamide , MBTH,Visible,Spectroscopic, Analytical method.