WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

ANTI-ULCER AND ANTIOXIDANT DEFENSES OF TARAXACUM OFFICINALE (DANDELION) LEAF EXTRACTS AGAINST ETHANOLINDUCED GASTRIC ULCER IN RATS

Berezi E. P.*, Uwakwe A. A., Monago-Ighorodje C. C. and Nwauche K. T.

Abstract

Objective: One of the common gastrointestinal diseases is ulcer caused by several necrotic agents. Synthetic commercial drugs had been used to cure this damage but with some side effects. The aim of this study is to investigate the antioxidant and ameliorative effects of aqueous extracts of T. officinale (T.O) on absolute ethanol - induced ulcer rats. Methods: Preliminary acute toxicity test of aqueous leaf extracts of T. officinale was performed, on which, two dose levels of 250mg/kgbw and 500mg/kgbw were selected for this study. Omeprazole (20mg/kg) was used as the standard drug. Results: Evaluation of rats treated with the extracts showed significant (p ≤ 0.05) decrease in the ulcer score index and an increase in the percentage inhibition. The catalase and glutathione antioxidant activities were reduced in the ulcer group with respect to the standard drugs and treated rats. Conclusion: These results indicate that T. officinale showed anti-ulcer and antioxidant defense properties against ethanol-induced gastric injury in a dose dependent manner.

Keywords: Taraxacum officinale extract (T.O.E), Omeprazole, Gastrointestinal, Catalase, Glutathione.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More