Abstract

OUTCOME OF METHOTREXATE THERAPY IN ECTOPIC PREGNANCY

Dr. Ebtihal Alsafi*

Abstract

Medical management has become very popular and effective in the treatment of ectopic pregnancy. Objectives: The objective of the study was to determine the incidence of ectopic pregnancy at King Abdul-Aziz Hospital in Taif city in the west area of Kingdom of Saudi Arabia, prevalence of available modality of treatment & to evaluate the efficacy & safety of medical therapy using single dose of methotrexate injection for heamodynamicaly stable intact ectopic pregnancy. Methods: This is a retrospective hospital based study of 350 women who were diagnosed as ectopic pregnancy at King Abdul Aziz Specialist Hospital, an experience of 3 years from 1st Jan 2014 to 31st Dec 2016 primary outcome measure was complete resolution of ectopic pregnancy confirmed by negative βhCG test following MTX therapy, secondary outcome measures were risk factors, success rate & side effects, causes of failure of medical therapy Results: 350 women with ectopic pregnancy were recruited for the study, 40 women were excluded from the study due to DAMA or lack of follow up, study was conducted on 310 women ectopic pregnancy account for 1% of maternities, tubal pregnancy was the most common type 95%, from these women 64.5 % (200) received medical therapy & achieved 87 % success rate with minimal side effects. Conclusion: Incidence of ectopic pregnancy was as it had been internationally, MTX is a safe & effective drug in the management of intact ectopic pregnancy in heamodynamicaly stable patients fulfilling the eligibility criteria & it is superior to surgical treatment regarding fertility conservation.

Keywords: Ectopic pregnancy, methotrexate, BhCG.