GLUCOSE TRANSPORTER TYPE 1 DEFICIENCY SYNDROME (GLUT1) AND USING KETOGENIC DIET IN TREATMENT OF DE VIVO DISEASE (A CASE REPORTS)
E. G. Lukyanova*, L. M. Sushko, S. O. Ayvazyan, K. V. Osipova, E. A. Pyreva, T. N. Sorvacheva, S. S. Zhilina and T. V. Kozhanova
Abstract
We present experience of ketogenic diet (KD) applying in the
treatment of pharmacoresistant epilepsy in a patients with glucose
transporter deficiency syndrome type I (GLUT1). We observed six
children with refractory epilepsy due to GLUT1. The high
effectiveness of KD in the treatment of GLUT1 was demonstrated. All
patients were achieved complete absence of seizures and EEG
abnormalities from the beginning of KD. We noticed positive shift in
cognitive and speech development for all children. Antiepileptic drugs
were stopped taking due to the stable remission. There was a further
positive dynamics in intelligence, psycho-emotional sphere; the
children began to go a nursery school and a special school. Thus, the
ketogenic diet is high effectiveness and, perhaps, the only method for GLUT1 treatment. For
100% of children with glucose transporter deficiency syndrome type I (GLUT1) using KD to
treating and prevention of all types of seizures. The improvement of the quality of life for
them we estimated by Hague scale. Using the KD we have achieved the reliable positive
changes in the psychomotor development of patients tested by Griffits 2, Griffits 3 scales.
Keywords: Ketogenic diet, pharmacoresistant epilepsy, intractable epilepsy, glucose transporter deficiency syndrome type I (GLUT1).
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