A REVIEW OF LIPID-POLYMER HYBRID NANOPARTICLES AS A DRUG DELIVERY SYSTEM
Rumpa Das*, Dr. Pulak Deb and Deitilin Lyngdoh
Abstract
Nano technologies have the potential to revolutionize the drug
development process and change the landscape of the pharmaceutical
industry. It is one of the most extensively explored area in the medical
science in the past few decades to develop a functional nanostructures
to facilitate the delivery of various therapeutic and imaging agents.
Liposomes and polymeric nanoparticles represent two primary delivery
vehicles that are being studied. While there are several advantages of
these two particle platforms, some intrinsic limitations remain to limit
their applications at a certain extent. Recently, a newer drug delivery
platform, named lipid-polymer hybrid nanoparticle, has been
developed that combines the positive attributes of both liposomes and
polymeric nanoparticles while excluding most of their shortages. The
nanoparticle consists of a hydrophobic polymeric core, a lipid shell surrounding the
polymeric core, and a hydrophilic polymer stealth layer outside the lipid shell. In this review,
we have discussed about the different method of synthesis of the lipid-polymer hybrid
nanoparticle, followed by a review of factors and typical characterization of the particles. We
then summarize the current and potential medical applications of the nanoparticle as a
delivery vehicle.
Keywords: Hybrid nanoparticle, liposome, polymeric nanoparticle, drug delivery vehicle, therapeutic agents.
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