WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

PHYTOESTROGENS: RECENT PERSPECTIVES ON THEIR CHEMISTRY AND BIOLOGY

Parna Das Sarma, Sanchita Bhattacharjee, Nivedita Bhattacharjee and Sauryya
Bhattacharyya*

Abstract

Polyphenols are present in all plants and the main classes of compounds that show phytoestrogenic activities are the isoflavones, the lignans, the coumestanes, the stilbenes and the mycotoxins. These compounds have structural and functional similarities with 17β- estradiol, which is the basis for their hormonal activity towards cellular estrogen receptors having beneficial role in humans against deficiency of estrogen. It has also been seen that different phytoestrogens exert their biological functions through different type of tissue specific receptors involving different mechanism of actions. Plant derived phytoestrogens bind with two types of estrogen receptors (ER) to put forth their mechanism of action: estrogen receptor α (ERα) and estrogen receptor β (ERβ), restricted in cytoplasm and nucleus. Phytoestrogens may exert their biological activity by one of the following mechanisms: mimicking the action of endogenous estrogen, functioning as estrogen antagonists, influencing the synthesis and metabolism of endogenous hormones, or by modifying hormone receptor biochemistry. A similarity between three dimensional arrangement of carbon atoms with estradiols might be the reason behind the pro-estrogenic action of the phytoestrogens.

Keywords: Phytoestrogen, 17?-estradiol, Isoflavones, Estrogen receptors, hormone.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More