Abstract

ANALGESIC ACTIVITY OF ETHANOLIC EXTRACT OF TAMARINDUS INDICA SEED COAT

Sirvi Someshver*, Sharma Urvashi, Dwivedi Sangeeta, Malviya Sapna and Kharia Anil

Abstract

The aim of the present investigation is to evaluate the analgesicactivity of ethanolic extract of Tamarindus indica seed coat onWisteralbino rat. Analgesic activity of the ethanolic extract ofTamarindusindica (EETI) seed coat at a dose of 350mg/kg & 500mg/kg wasevaluated against the standard drug Pentazocine at a dose of 10mg/kg.Adult Wister albino rat of either sex was divided in to 4 groupscomprising six numbers in each group was undertaken for study andevaluated by tail flick method & hot plate method. The two doses of T.indica seed coat ethanolic extract was found to produce significant (p <0.05 and p<0.01) analgesic activity. In tail flick method, the crudeextract produced elongation of time 30 minutes after oral dose of 350and 500 mg/kg body weight respectively. Test drug at a dose of 500mgshowed better analgesic activity in comparison to 350mg dose by both the methods. So, it canbe recommended for further studies.

Keywords: Analgesic, Tamarindus indica, Pentazocine, Ethanolic extract.