FORMULATION AND EVALUATION OF CONTROLLED RELASE OF BUCCOADHESIVE BILAYERED BUCCAL TABLET OF NIFEDIPINE
Vineela Sangu*, R. Anusha Naik, Ajay Kumar D., B. Preethi Reddy and B. Dharani Priyanka
Abstract
The aim of the present study was to design buccoadhesive bilayered
tablets to release the drug unidirectionally in buccal cavity for
extended period of time in order to avoid first-pass metabolism for
improvement in bioavailability, to reduce the dosing frequency and to
improve patient compliance. An attempt has been made to develop
buccoadhesive bilayered tablets comprising of drug containing
bioadhesive layer and drug free backing layer to release the drug for
extended period of time with reduction in dosing frequency. Tablets of
nifedipine were prepared by direct compression method using
bioadhesive polymers like Carbopol 934P, Methocel E15, and sodium
carboxy methyl cellulose either alone or in combinations with backing layer of ethyl
cellulose. The preformulation blend was shown good flow properties with good angle of
repose, bulk density and tapped density parameters. The formulated tablets were evaluated
for various quality control parameters and they were passed all the tests with standard values
as per pharmacopoeia. Slow, controlled and complete release of Nifedipine over a period of 8
hours was obtained from matrix tablets formulated employing HPMC E15 and Carbopol
934P (F7 Formulation). This tablets exhibited good buccoadhesion. Good oral controlled
released bilayered buccoadhesive tablet formulation of Nifedipine could be developed using
HPMC E15 and Carbopol 934P.
Keywords: Nefidipine, Carbopol, Sodium CMC, Buccal tablets.
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