INVESTIGATION OF ANTI-UROLITHIATIC ACTIVITY OF LINUM USITATISSIMUMAND MIMOSA PUDICA IN EXPERIMENTALLY INDUCED UROLITHIASIS IN ANIMAL MODELS
*R. Naga Kishore
Abstract
Objectives: The present study was undertaken to evaluate the effects
of some traditional medicinal plants i.e., Linum usitatissimum and
Mimosa pudica in combination and in alone on experimentally-induced
(urolithiasis) kidney stones. Methods: Urolithiasis in animals was
induced experimentally by administration of ethylene glycol (0.75%
v/v) with ammonium chloride (1% w/v) in drinking water for ten days.
The aqueous extract of both plants were administered alone and in
combination to urolithiasis induced test group rats at a dose of 400
mg/kg respectively for 10 days. After 10 days, renal function
parameters measured such as increase in the urine urea, uric acid, and calcium and creatinine
levels, which reflect the deposition of calcium oxalate in the kidneys. Results: The serum
analysis showed significant increase in the serum uric acid, serum creatinine, blood urea and
calcium in urolithiasis control group rats. In addition, vehicle treated induction control group
rats showed significant increase in the biochemical parameters. Conclusion: Daily oral
treatment with all most all extracts not significantly decreased the quantity of calcium oxalate
deposited in the kidneys but also reverted all the biochemical changes induced by calcium
oxalate urolithiasis thus supporting its traditional claim. Aqueous extract of both plants in
combination and in alone was found to be significant when compared with standard and
control group.
Keywords: Urolithiasis, Creatinine, Mimosa pudica, Linum usitatissimum.
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