ANTI-INFLAMMATORY ACTIVITY OF FLUEGGEA LEUCOPYRUS LEAF ON CARRAGEENAN AND COTTON PELLET GRANULOMA INDUCED INFLAMMATORY RATS
Rajeswari B. and Muthuirulappan Srinivasan*
Abstract
Inflammation is a part of the complex biological response of vascular
tissues to harmful stimuli, such as pathogens, damaged cells or
irritants. It is characterized by redness, swollen joints, joint pain, its
stiffness and loss of joint function. Inflammation is currently treated by
NSAIDs. Unfortunately these drugs cause increased risk of blood clot
resulting in heart attacks and strokes. Therefore, the developments of
potent antiinflammatory drugs from the natural products are now under
considerations. Natural products are rich source for discovery of new
drugs because of their chemical diversity. A natural product from
medicinal plants plays a major role to cure many diseases associated
with inflammation. The conventional drug available in the market to
treat inflammation produces various side-effects. Due to these sideeffects,
there is need for the search of newer drugs with less or no sideeffects.
In the present study to investigate the anti-inflammatory activity of Flueggea
leucopyrus leaf on carrageenan and cotton pellet granuloma induced inflammatory rats. The
current evidence from experimental studies demonstrate that supplementation of Flueggea
leucopyrus leaf extract (FLLE) has potential anti-inflammatory activity in inflammatory rats.
Significantly decreased the paw volume in carageenan and cotton pellet method. Our study
confirms that FLLE plays duel role by blocking inflammatory reaction. Over all, the
experimental studies suggest that Flueggea robustra leaf extract (FLLE) possess antiinflammatory
activity.
Keywords: Flueggea leucopyrus leaf, Inflammation, Carageenan, cotton pellet granuloma.
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