Abstract

ANTI-INFLAMMATORY ACTIVITY OF FLUEGGEA LEUCOPYRUS LEAF ON CARRAGEENAN AND COTTON PELLET GRANULOMA INDUCED INFLAMMATORY RATS

Rajeswari B. and Muthuirulappan Srinivasan*

Abstract

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, its stiffness and loss of joint function. Inflammation is currently treated by NSAIDs. Unfortunately these drugs cause increased risk of blood clot resulting in heart attacks and strokes. Therefore, the developments of potent antiinflammatory drugs from the natural products are now under considerations. Natural products are rich source for discovery of new drugs because of their chemical diversity. A natural product from medicinal plants plays a major role to cure many diseases associated with inflammation. The conventional drug available in the market to treat inflammation produces various side-effects. Due to these sideeffects, there is need for the search of newer drugs with less or no sideeffects. In the present study to investigate the anti-inflammatory activity of Flueggea leucopyrus leaf on carrageenan and cotton pellet granuloma induced inflammatory rats. The current evidence from experimental studies demonstrate that supplementation of Flueggea leucopyrus leaf extract (FLLE) has potential anti-inflammatory activity in inflammatory rats. Significantly decreased the paw volume in carageenan and cotton pellet method. Our study confirms that FLLE plays duel role by blocking inflammatory reaction. Over all, the experimental studies suggest that Flueggea robustra leaf extract (FLLE) possess antiinflammatory activity.

Keywords: Flueggea leucopyrus leaf, Inflammation, Carageenan, cotton pellet granuloma.