ANTIULCEROGENIC ACTIVITY OF ETHANOLIC EXTRACT OF MORINGA OLEIFERA BARK IN WISTAR ALBINO RATS
Ch. Anunya*, Vivek Tiwari, Dr. P. Veresh Babu and Dr. M. Gangaraju
Abstract
The present study was under taken to evaluate Antiulcer activity of
Ethanolic bark extract of Moringa oleifera against ethanol and acetic
acid induced ulcer models. Ethanol is widely used ulcerogenic agent
which induces acute gastric ulcers, ethanol induced ulcers which is
associated with significant production of o2 free radicals leading to
lipid peroxidation with consequent damage to cell and cell membrane.
Moringa oleifera significantly protects the gastric mucosa against the
ethanol challenge, as shown by the reduced values of ulcer index. The
extract had shown dose dependent significant effect when compared to
ethanol control group. Acetic acid induced chronic ulcer model is
another classical model for evaluation of antiulcerogenic activity. Exposure to glacial acetic
acid produces deep penetrating gastric ulcers with clear vascular injury, edema, hemorrhagic
streaks, epithelial thickening and necrotic lesions. The bark extract of the plant had shown
pronounced dose dependent protective effect evident by reduced ulcer index. The activity of
the extract was found to be significant compared to acetiacid control group in which there
was enhanced ulcer index and perforations. The histopathology examination was carried out
to determine effect of extracts. These were selected to reflect rate and healing of ulcers. The
parameters suggested that the pre-treated rats with ethanolic extract of Moringa oleifera bark
(200 mg/kg) or Omeprazole (20 mg/kg) orally significantly reduced the formation of gastric
ulcer.
Keywords: Moringa oleifera, Omeprazole, ethanol, acetic acid.
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