Abstract

STANDARDIZATION OF ALLOXAN DOSE TO INDUCE STABLE EXPERIMENTAL DIABETES IN RATTUS NORVEGICUS

Lalit P. Dewalkar and Suresh Masram*

Abstract

Alloxan widely used as diabetogenic agent but when compared with streptozotocin, most workers preferred later. The present work investigated standard alloxan dose and age of the rat for stable experimental diabetes. The rats of the age 6, 9, 12 and 15 months were divided into four batches as batch 1, 2, 3 and 4. Each batch of the rat further divided into G1, G2, G3 and G4 on the basis of alloxan dose received i.e. 120, 140, 160, and 180 mg/kg b.w of intraperitoneal alloxan. In conclusion the works established standard alloxan dose of 180mg/kg b. w. in 9 month old rat as stable diabetic model.

Keywords: Alloxan, Diabetogenic, Streptozotocin, intraperitoneal, diabetic model.