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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI OXIDANT ACTIVITY OF NOVEL CHALCONES AND DI HYDRO PYRIMIDINENONES DERIVATIVES

P. S. Raghu*

Abstract

Novel chalcones were synthesized by condensing 1-(2-chlorophenyl) ethanone with aromatic aldehydes derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Clasein- Schmidt condensation reaction. The synthesized chalcones compounds were reacted with urea and ethanol upon cyclisation gives pyramidinone derivatives. All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. The antioxidant activity done by DPPH method the results were compared with standard ascorbic acid.

Keywords: Chalcones, Pyrimidinone, Antimicrobial activity, Clasein-Schmidt condensation.

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