WJPR Citation New

  All Since 2019
 Citation  7475  4312
 h-index  28  21
 i10-index  197  83

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

TRANSDERMAL PATCHES OF VALSARTAN: FORMULATION AND EVALUATION

Bhawana Sethi, Anil Kumar Sahdev*

Abstract

Transdermal drug delivery system has been seen a veritable explosion in the past decades. In the present scenario, very few transdermal patches are available. Matrix-diffusion type transdermal film of valsartan was designed with various concentration of HPMC (k4M, K15M, K100M). Valsartan is a nonpeptide angiotensin II AT1 receptor antagonist and very well-tolerating hypertension by specifically blocking the action of angiotensin-II on the angiotensin Type-1 receptor. The drug has 23% bioavailability with biological half life of 7.5h. The result of the formulation E was showing weight variation(0.0519 ± 0.0004), percentage moisture absorption (3.45 ± 1.08), percentage moisture loss (4.8 ± 1.14), water vapour transmission rate (0.46 ± 0.015g/hr/cm2), thickness (0.056 ± 0.005mm), Folding endurance (1033.67 ± 7.094), tensile strength (0.379 ± 0.006 kg/mm2). In vitro release studies showed zero-order release from all the patches. The permeation was studies were carried out for 24h showing release up to 39%. Stability studies are carried out for 7 weeks and indicates that drug remain stable for that period and primary irritation studies indicated that the transdermal patches are non irritant.

Keywords: Transdermal patches, Valsartan, HPMC, Hypertension.


[Full Text Article]  [Download Certificate]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More