Abstract

PHARMACEUTICAL APPLICATION OF PIGMENTS HAVING PHYTOCHEMICAL LIKE COMPOUNDS FROM FUNGI

Dr. D. R. Majumder*, Misbah Upade, Gitanjali Jogale and Jyoti Salvi

Abstract

Production of bioactive compounds from fungi is very useful commercially because they lead to high productivity in less time. Fungi are known to produce a wide range of natural compounds during their growth as intermediate metabolites which include alkaloids, tannins, flavonoids and terpenoids. Screening of fungi was performed for production of pigments from different environmental conditions. Their growth and pigment production was optimized at 28°C ± 1°C. These strains were Fusarium sp which produced MJGD1, Trichoderma sp which produced MJGD2 and MJGD3, Aspergillus sp which produced MJGD4 and Penicillium sp which produced MJGD5, MJGD6 and MJGD7 pigments respectively. Maximum production was observed in potato dextrose broth. Crude extract was subjected to TLC and MJGD1, MJGD3, MJGD4 and MJGD5 showed fluroscence under UV. Antimicrobial activity was checked against Staphylococcus aureus NCIM 2079 by well diffusion method where MJGD1, MJGD6 and MJGD7 displayed inhibitory zone of 21mm, 22mm and 24mm respectively. FTIR analysis revealed that pigments are multicomponent in nature. Qualitative test of the fungal pigments were also performed which showed presence of Glycosides, Flavonoids, Alkaloides and Terpenoids which are known phytochemicals.

Keywords: Fusarium sp, Trichoderma sp, Aspergillus sp, Penicillium sp, Fungal pigments, antimicrobial activity, alkaloids, glycosides, flavonoids, terpenoids, FTIR, TLC.