Abstract

BIOGENIC COPPER NANOPARTICLES FROM MEDICINAL PLANTS AS NOVEL ANTIDIABETIC NANOMEDICINE

Tanay R. Bhagwat, Komal A. Joshi, Vijay Singh Parihar, Adersh Asok, Jayesh Bellare, Sougata Ghosh*

Abstract

In an attempt to design rapid, efficient and eco-friendly process to fabricate nanoparticles with potent biomedical applications, herein we report for the first time synthesis of copper nanoparticle (CuNPs) using three medicinal plants, B. prionitis leaf extract (BPLE), L. chinensis peel extract (LCPE) and P. orientalis leaf extract (POLE). The synthesis was completed within 5 h indicated by visible colour change and UV-visible spectroscopy. High resolution transmission electron microscopy revealed that the bioreduced CuNPs were very small. CuNPs synthesized by BPLE were between 11 to 15 nm while for POLE they were between 90 to 200 nm. LCPE synthesized CuNPs in a size range between 10 to 100 nm. Further the CuNPs were characterized using energy dispersive spectroscopy (EDS), dynamic light scattering (DLS) and fourier transform infrared spectroscopy (FTIR). Both α-amylase and α-glucosidase were found to be inhibited by the CuNPs providing the strong rationale for their further use in clinical studies as candidate nanomedicine against Type II Diabetes Mellitus.

Keywords: Barleria prionitis, Litchi chinensis, Platanus orientalis, copper nanoparticle, ?-amylase, ?-glucosidase.