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Abstract

SYNTHESIS AND EVALUATION OF ANTI-BACTERIAL POTENTIAL OF IMINE ANALOGS DERIVED FROM DIFFERENT SUBSTITUTED 3-ACETYL INDOLE AND AMINO PYRAZINE

Tambat Nazia*, Koli Mahesh, J. K. Oberoi

Abstract

Despite the presence of large number of antibiotics, drug resistant species have become a major concern. The quest for better antimicrobial compounds against drug resistant species exhibiting minimum toxicity and higher therapeutic index is very relevant in present scenario. Indole and Pyrazine have been earlier explored for their biological activity in particular for their antimicrobial activity. In the present work, synthesis and characterization of a series of novel imine derivatives containing pyrazine and acetyl indole is reported along with results of in vitro studies for the determination of their activity against Escherichia coli and Staphylococcus aureus. Based on the data Compound 4 showed the most potent activity against the tested bacterial strains.

Keywords: Indole, Pyrazine, Antibacterial, Imine derivatives.


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