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Abstract

THE POTENTIAL ANTIOXIDANT AND HEPATOTOXICITY OF METHANOLIC EXTRACT OF LEAVES OF LIBYAN CAPPARIS SPINOSA SUBSP ORIENTALIS (DUH.) JAFRI IN RATS

Salwa I. Eltawaty*, Mohamed Elfatih A. Omare, Aisha Z. Almagboul, Tarig M. El-Hadiyah, Amna E. H. Mohammad and Saleh M. Bofarwa

Abstract

Objective: The study aimed to investigate antioxidant activity, acute and sub-acute toxic potential of methanolic extract of leaves of Libyan Capparis spinosa subsp orientalis (Duh.) Jafri in rats. Methods: LD50 of methanolic extract of leaves of Libyan apparis spinosa subsp orientalis (Duh.) Jafri was determined according to El-Hadiyah et al. (2011). Changes in behavioral response were recorded.Antioxidant activity evaluated with use of DPPH scavenging assay. Results: LD50 of methanolic extract of the plant leaves was found to be more than 2g/kg. Regarding the effect of single dose of 1g/kg of methanolic extract of leaves of Capparis spinose injected IP to rats for one week, no significant changes in serum levels of liver enzymes of treated group compared to normal group. Although histopathological examination of the liver of treated rats showed hepatocellular necrosis, congestion, heamorrage and cytoplasmic vacuoles. Amoderate intermittent spasms started after 90 minutes and lasted for an hour intermittently then disappeared. The study showed that the plant revealed an antioxidant activity 80% with IC50 0.2mg/ml ± 0.07. Conclusion: Libyan Capparis spinose has good antioxidant activity. The lethal dose of the methanolic extract of the plant leaves is more than 2000mg/kg. No significant differences showed in liver safety biomarkers; alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), but it showed hepato-changes on liver tissue.

Keywords: Antioxidant, LD50, hepatotoxicity, Capparis spinosa.


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