Abstract

SEMICARBAZONE DERIVATIVES AND THEIR PHARMACOLOGICAL ACTIVITIES

Suman Lata Rawat*, Anita Singh and D. K. Sharma

Abstract

Epilepsy can be devastating to patient’s day to day life. Different categories of antiepileptic agents are present in market but they have toxic effects on central nervous system. Aryl and heteroaryl semicarbazone derivatives present a new area of interest as anticonvulsant drugs. Semicarbazones have been widely synthesized for their anticonvulsant properties. Many semicarbazones have shown better activity and low neurotoxicity than already available drugs, therefore they can be used as lead compounds for the synthesis of newer antiepileptics. Various semicarbazones have been synthesized which possess different pharmacological activity in addition to antiepileptic activity.

Keywords: antiepileptic, semicarbazones, maximal electroshock seizure (MES), subcutaneous strychnine (scSTY) and subcutaneous penatylenetetrazole (scPTZ), gammaaminobutyric acid aminotransferase (GABA-AT).