Abstract

“EFFECT OF ETHANOLIC EXTRACT OF CESTRUM NOCTURNUM LEAVES ON BLOOD GLUCOSE LEVEL OF STREPTOZOTOCININDUCED DIABETIC ALBINO WISTAR RATS”

Lokendra Singh*, Gaurav Sharma, Pooja Sharma and Deepak Godara

Abstract

Aim: To evaluate blood glucose level after oral administration of Ethanolic extract of leaves of Cestrum nocturnum for 4 weeks. Method: Extract of leaves of the trial drug was prepared with the help of soxhlet extraction technique using ethanol as a solvent. 18 Diabetes induced albino wistar rats were divided in three groups (Negative control, Test group and Standard Group). Negative control was administered 5 ml/kg/p.o. normal saline. Test group was administered 400 mg/kg/p.o. leaves extract of Cestrum nocturnum. Standard Group was administered 10mg/kg/p.o. metformin. Duration of treatment: 4 weeks. Evaluation: Blood glucose levels and body weights of rats were measured at the end of first, second, third and fourth week. Results: Oral administration of the extract for 4 weeks caused a significant (𝑃 < 0.01) reduction in blood glucose level in diabetic rats. The body weight of diabetic animals was also improved after daily administration of the extract.

Keywords: Cestrum nocturnum, antidiabetic, leaves extract.