Abstract

A STUDY OF BIOCHEMICAL PARAMETERS IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS DIAGNOSED FOR MYOCARDIAL INFARCTION

Cedrick Izere, V. Chitrasree, S. Jayanthi, C. Deepa, V.T. Musthafa, E. chitkara and G. R. Neel*

Abstract

Aims: Coronary heart disease (CHD) is currently the leading cause of death worldwide and together with diabetes, poses a serious health threat, particularly in the Indian Asiatic population. Methods: A retrospective observational study on biochemical parameters in patients with and without diabetes diagnosed for myocardial infarction was conducted at Madras Medical hospital located in Chennai/Tamilnadu/India. Results: The result of this study showed that out of 200 subjects, 160 were males and 40 were females, and amongst them 149 were found to be Diabetic and 51 were found to be Non Diabetic. The outcome of this study revealed that there is a strong association between diabetes mellitus and heart diseases. There is significant increase in the level of Troponin I to be recognised as a single parameter to confirm the diagnosis of Myocardial Infarction. More than 75% of people have responded at minimal elevated value of Troponin I. There was no significant correlation in the level of troponin I amongst diabetic and non-diabetic. There was a statistically significant difference in the HBA1C level amongst diabetic and non-diabetic though there was no such significant in the other parameter (Lipid profile, SGOT, SGPT and LDH). There was a significant increase in urea over the treatment phase. There was a considerable percentage of samples with deranged renal function with background of diabetes at the onset of MI. Conclusion: Diabetes mellitus is considered as a risk equivalent for coronary artery disease; hence routine screening for both coronary artery disease and diabetes in the patients is justified.

Keywords: Diabetes mellitus, HBA1C, Myocardial infarction, Troponin I.