Abstract

ENHANCEMENT OF SOLUBILITY & DISSOLUTION RATE OF POORLY SOLUBLE DRUG OF NATEGLINIDE BY LIQUISOLID TECHNIQUE

Chandra Sekhar Naik D.*, Ramana G., Dedeepya G. and Bhargavi C. H.

Abstract

The main aim of the present investigation is to enhance the dissolution rate of poorly water soluble drug such as Nateglinide. In this technique liquisolid system refers to formulation prepared by water insoluble drug mix with non-volatile solvent which is further converted into free flowing, non adherent powder form and which is directly compressed into tablets. In that the propylene glycol is used as non-volatile solvent in which drug having high solubility. Formulations F1,F2,F3were prepared by using microcrystalline cellulose and aerosil (silica),F4,F5,F6 were prepared by using lactose and cab-o-silica & F7 to F9 were prepared by using lactose and Syliod 244FP as carrier and coating material in the ratio of 10:1 and 20:1 respectively. Sodium starch glycolate acts as superdisintegrant and magnesium stearate as glidant in liquisolid system. The prepared liquisolid system were evaluated to their flowing properties such as bulk density, tap density, Hausner’s ratio, Carr’s index, and angle of repose. Fourier Transform Infrared spectroscopy (FTIR) and X Ray Diffraction (XRD) study shows no interaction between the drug and excipients. Further tablets were evaluated for hardness, diameter, thickness, weight variation, friability, disintegration test, uniformity of contents and in-vitro release study the studies shows liquisolid compact exhibited higher percentage of drug release than conventional and marketed tablets because of due to increase in wetting properties and surface availability for dissolution.

Keywords: Nateglinide-Liquisolid Compacts, Direct Compression, In-vitro Dissolution Study.