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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF 6-ARYL- 3- CYANO-4-[4â€™-(p-METHYLBENZYLOXY)-3â€™- METHOXYPHENYL]-2- OXO-1,2-DIHYDROPYRIDINES

Jagdish V. Dodia*

Abstract

Some new of 6-Aryl-3-cyano-4-[4’-(p-methylbenzyloxy)-3’- methoxyphenyl]-2-oxo-1,2-dihydropyridines (2a-l) have been prepared by the condensation of chalcones of 1-Aryl-3-[4’-(pmethylbenzyloxy)- 3’-methoxyphnyl]prop-2-en-1-ones (1a-l) with ethylcyanoacetate in presence of ammonium acetate. All the prepared Cyanopyridine derivatives compounds were characterized by their spectral (I.R., N.M.R., Mass) data and screened for their antimicrobial activities.

Keywords: Chalcone, Cyanopyridine derivatives, Antimicrobial Activities.

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