Abstract

PRELIMINARY ACUTE ORAL TOXICITY STUDY OF A NEWLY DEVELOPED HERBAL FORMULATION

Soumendra Darbar, Srimoyee Saha, Kausikisankar Pramanik and Atiskumar Chattopadhyay*

Abstract

Toxicity is an expression of being poisonous, indicating the state of adverse effects led by the interaction between toxicants and cells. Acute toxicity studies are conducted to evaluate the effects of a single substances on animal model. The present study was designed to evaluate the acute oral toxicity study of herbal formulation (HF) according to OECD guidelines. In the present study, a single administration of the poly herbal extract at a dose of 2000 mg/kg, respectively, was given to the mice. Mice were observed for general appearance, behavior, body weight, adverse effects, mortality and necropsy up to 14 days post-treatment. In this study we could not find any mortalities during the experimental period. No changes in general appearance and mortality was observed. HF was found to be safe at dose of 2000mg/kg. In the conclusion these results demonstrate that the extract may not have any single dose toxicity.

Keywords: Acute toxicity; Herbal formulation; OECD guidelines; Necropsy.