Abstract

A REVIEW ON CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF EZETIMIBE AND FLUVASTATIN

Shivani T. Raval* and Dr. Dilip G. Maheshwari

Abstract

Ezetimibe is selective cholesterol absorption inhibitor. It is an antihyperlipidemic agent. It is used in treatment of Hypercholesterolemia. Fluvastatin is a drug which comes under class of statin. It is used to reduce cholesterol levels and prevent cardiovascular disease. It decreases low density lipoprotein (LDL) cholesterol. Ezetimibe plus Fluvastatin was proved to be effective at a dose of 10mg and 80mg in management of hypercholesterolemia compare to Ezetimibe and Fluvastatin Monotherapy. Cholesterol absorption inhibitor plus statin showed the effective results in relief of the Hypercholesterolemia. This article narrate different chromatographic (HPLC, HPTLC) and different spectrophotometric method (UV) for determination of the Ezetimibe and Fluvastatin.

Keywords: Ezetimibe, Fluvastatin, UV- Spectroscopy, HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography).