Abstract

EVALUATION OF THE ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF THE PLANT ALPINIA NIGRA (FAMILY: ZINGIBERACEAE)

Syeda Sadia Ameen, Syeda Rawnak Jahan, Md. Yousuf Ali

Abstract

Alpinia nigra is an important medicinal plant having application in jaundice, fever and various other disorders. The aim of this study was to evaluate the anti-inflammatory and antipyretics activities of the whole plant A. nigra. The roots, stems, barks and the leaves of the plant A. nigra was sun dried and extracted using methanol. The antiinflammatory activity was evaluated using the carageenan induced paw edema in rats. The crude methanolic extract at a dose of 600mg/kg showed very potent anti-inflammatory activity in carageenan induced rat paw edema model with 68.59% inhibition of paw edema after the fourth hour of study. The Antipyretic activity was evaluated by the yeast induced pyresis method. The crude methanolic extract at both 600mg/kg and 300mg/kg dose showed significant Antipyretic effect.

Keywords: Alpinia nigra, carageenan, paw edema, yeast induced pyresis.