Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF BIS-PYRAZOLES USING 1-PTOLYLPYRROLIDINE- 2, 5-DIONE

S. S. Patole* and Dr. S. S. Rajput

Abstract

In the present work we have used the green and efficient synthesis for new series of bis-pyrazoles derivatives from 1-p-tollylpyrrolidine-2,5- dione under microwave irradiation. The 1-p-tolylpyrrolidine-2,5-dione was synthesized from succinic acid and p-toludine using thionyl chloride. The cyclic imides condensed with substituted aromatic aldehydes using solid support neutral Al2O3 in microwave. The resulting chalcone derivative underwent ring closer with phenyl hydrazine in presence of neutral Al2O3 under microwave irradiation afforded bis-pyrazole derivatives. All pyrazole derivatives were characterized by spectral and elemental analysis and these derivatives were screened for their antibacterial activity.

Keywords: 1-p-tollyl pyrrolidin e -2,5-dione, phenyl hydrazine.