Abstract

HIGHLY ACTIVE ANTI-RETROVIRAL THERPY INDUCED ANEMIA

*Dr. L. Siddartha, N. Jhansirani, D. Laharika, S. Tejaswini and Dr. Rama Mohan Gupta

Abstract

A Female patient of age 60years was admitted in the hospital with complaints of Breathlessness, cough, mild expectoration& abdominal pain since 1week, and has a history of loss of appetite. The patient had a past medical history of HTN (treated with AMLODIPINE), HIV (treated with zidovudine and RIBAVIRIN). Her lab investigations showed decreased Hb levels (5.5gm/dl), RBC (1.44million cells/cumm), WBC (3200cells/cumm), PCV (12.4%) &BP-(150/90mm hg). As she has been on treatment with zidovudine and ribavirin, these drugs will induce anemia and hence has to be monitored proportionately. The presented complaints of the patient are treated well significantly. To reduce the adverse effects of zidovudine and ribavirin, an alternative drugs like didanosine & abacavir (NNRTIS) with indinavir (protease inhibitors) can be chosen as a standard goals of therapy.

Keywords: HTN (hypertension), NNRTIS (non-nucleoside reverse transcriptase inhibitors), Anemia, HAART (highly active anti retroviral therapy).