Abstract

NOVEL APPROACH FOR SPECTROPHOTOMETRIC ESTIMATION OF PIROXICAM IN TABLET DOSAGE FORM USING CO-MELT OF SODIUM ACETATE TRIHYDRATE AND RESORCINOL AS ECOFRIENDLY SOLVENT (MIXED SOLVENCY CONCEPT)

R. K. Maheshwari, Mitali Shah and Tilotma Sahu*

Abstract

The pollution and toxicity caused by most of the organic solvents is a big challenge. The researchers are doing much work to give ecofriendly solutions for this challenge. Maheshwari has given a nice concept, known as mixed-solvency concept. By application of this concept, innumerable solvent systems can be developed. Maheshwari is of the opinion that each substance possesses solubilizing power. He has given several eco-friendly methods in the area of drug estimations and formulations precluding the use of toxic organic solvents. The present research work also provides an eco-friendly method to estimate spectrophotometrically, a poorly water-soluble drug, piroxicam in tablet formulations without the help of organic solvent. The present investigation is an attempt to show that solids can also be wisely used to act as solvent precluding the use of organic solvents. The main objective of the present study is to demonstrate the solvent action of solid. In the present investigation melted sodium acetate trihydrate and resorcinol were employed as solubilizing substances to extract out the drug to estimate piroxicam tablets spectrophotometrically At 358 nm. Sodium acetate trihydrate and resorcinol do not interfere in spectrophotometric analysis At 358 nm. Proposed method is novel, economic, ecofriendly, rapid, free from toxicity of organic solvent, accurate and reproducible. Recovery studies and statistical data proved the accuracy, reproducibility and precision of the proposed method. The presence of tablet excipients and co melt did not interfere in the spectrophotometric estimation at 358 nm.

Keywords: Mixed-solvency concept, piroxicam, sodium acetate trihydrate, resorcinol, spectrophotometric analysis.