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Abstract

FORMULATION AND EVALUATION OF DISULFIRAM TABLETS, 500 MG

Venkateswaran Chidambaram Seshadri*, Packiaraj Jeyachandran Manohari,
Janakiraman Kunchithapatham and Jayanarayan Kulathingal

Abstract

There are few manufacturers available in the market worldwide for Disulfiram Tablets. There is report of high bio variability reported between the marketed, effervescent/dispersible tablets vis a vis immediate release tablets.[1-6] In the present research, Disulfiram Tablets were manufactured by wet granulation process. Manufactured tablets showed good morphology and mechanical strength, without tableting issues. In this research influence of milling and micronization of API on the in vivo bio variability of the drug product was studied and reported.

Keywords: Milling, Micronization, Wet granulation, Core tablet and Bioequivalence under Fasting.


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