Abstract

HEPATOPROTECTIVE ACTIVITY OF POLYHERBAL CURNA (CHURNA) ON ETHANOL MEDIATED PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

Dr. Venu Sampath Kumar Golla*

Abstract

Ethanol is widely used drink in beverages and paracetamol is widely used drug throughout the world. Among the chronic alcoholics Paracetmol induced hepatotoxicity is very severe. The present study was extended to the combined model of ethanol and paracetamol because in order to combat the severe hepatotoxicity produced by combined effect of ethanol and paracetamol, no single plant derivative or isolated active principle is sufficient. Hence a polyherbal formulation of mixture of plant derived products is essential. The polyherbal churna was prepared by mixing dried aqueous extract powders of barks of Alstonia scholaris, Ficus bengalensis, Pongamia pinnata and Ricinus communis in equal quantities. The prepared churna was evaluated for hepatoprotective activity against the paracetamol and ethanol induced hepatotoxicity. The hepatic damage in rats was evidenced by elevated levels of SGPT, SGOT, ALP, Total protein and Total bilirubin. Ethanol mediated Paracetmol induced hepatotoxicity was treated with churna showed significant activity by comparing with silymarin and the results were further supported by histopathological studies.

Keywords: Hepatoprotective activity, polyherbal churna, Ethanol, Paracetmol, Silymarin.