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Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 2-{1’-ARYL-1’-[4’’- (2’’’-HYDROXY ETHOXY ETHYL) PIPERAZIN-YL]-METHYL}- CYCLOHEXANONE HYDROCHLORIDE

Rakesh P. N. Roshan, D. M. Purohit and Sandip K. Matariya*

Abstract

2-{1’-Aryl-1’-[4’’-(2’’-hydroxyethoxy ethyl)piperazin-yl]-methyl}- cyclohexanone hydrochloride (4a-4l) have been synthesized. The products have been assayed for their antimicrobial activity against Gram+ve, Gram-ve bacteria and fungi. All the products were assigned with IR, 1HNMR, Mass Spectra, TLC, and elemental analysis. Some of the products showed moderate activity, compare with known standard drugs.

Keywords: Gram+ve, Gram-ve bacteria and fungi.


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