Abstract

A REVIEW ON CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF OPIPRAMOL DIHYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

Purvangi S. Patel* and Dr. Dilip G. Maheshwari

Abstract

Opipramol dihydrochloride is an Antidepressantand Anxiolyticdrug. It is a member of the tricyclic antidepressants, opipramol'sprimary mechanism of actionis much different in comparison. MostTCAs act as reuptake inhibitors, but opipramol dihydrochloride doesnot, and instead acts as a sigma receptor agonist. This is generallyadministered as tablet dosage form. Mostly the work is done on RPHPLCwith different methods and for its estimation the mobile phaseused are usually the same that are in different ratio of Acetonitrile andPotassium Dihydrogen Orthophosphate. This review entails thedifferent methods for estimation of Opipramol dihydrochloride likeUV, HPTLC, HPLC, LC.

Keywords: Opipramol dihydrochloride, Antidepressant, stability indicating method, UVspectroscopy, HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography), LC (Liquid Chromatography).