Abstract

A REVIEW ON CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF RIVAROXABAN AND TICAGRELOR

Ayushi R. Mehta* and Dr. Dilip G. Maheshwari

Abstract

RIVAROXABAN is a drug which belongs to class of anticoagulant.Rivaroxaban is approved for the prevention of strokes and systemicembolism in atrial fibrillation. It is useful in prevention blood clot andtreatment of deep venous thrombosis. TICAGRELOR is a plateletaggregation inhibitor which is an antagonist of the P2Y12 receptor ofthrombotic events in acute coronary syndrome or myocardial infarctionwith ST elevation Combination of Rivaroxaban and Ticagrelor wasProved to be effective in Atrial fibrillation compare to Rivaroxabanand Ticagrelor monotherapy. This review entails different methoddeveloped for determination of the Rivaroxaban and Ticagrelor likeUV-spectroscopy, liquid chromatography, HPTLC and HPLC.

Keywords: Rivaroxaban, Ticagrelor, UV- Spectroscopy, HPLC (High Performance Liquid Chromatography), HPTLC (High Performance Thin Layer Chromatography), LC (Liquid Chromatography).