Abstract

GC-MS ANALYSIS AND INVITRO ENZYME INHIBITORY EFFECT OF DIFFERENT SOLVENT EXTRACTS OF GARCINIA CAMBOGIA FRUIT

S. Swetha, *V. Anuradha, N. Yogananth and M. Syed Ali

Abstract

The objective of the present study was to identify bioactive compounds, quantification of preliminary secondary metabolites and to determine its anti obese and anti diabetic activity through invitro enzyme inhibitory effect on pancreatic amylase and Lipase. The presence of phytoconstituents was determined by GC-MS analysis. Thirty four compounds were identified in Garcinia gummi-gutta (L.) Roxb fruit extract by GC-MS analysis. The hexane extract was found to contain high amount of Phenolics, flavonoids and Tannins. The ethyl acetate extract showed potent inhibitory activity with an IC 50 value of 55.87 ± 0.60 and 83.33 ± 0.47 against both amylase and Lipase respectively.

Keywords: Garcinia cambogia, GCMS Analysis, Pancreatic amylase and Pancreatic Lipase.