Abstract

DESIGN, FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELUIVERY OF LORNOXICAM

R. B. Desireddy, Ch. Sunil Kumar*, S. K. Salman, T. Vinod Kumar, T. Eswar Sai and Badri Kumar

Abstract

The aim of the present research work was to develop lornoxicam colon targeted tablets using polymers HPMC, Ethyl cellulose as carriers in various concentrations. Sustained Release tablets were prepared by direct compression method. Prepared formulations were subjected to various pharmacopoeial tests like hardness, friability, thickness, % drug content, weight variation, In-vitro drug release study etc. from the results conluded that all were with in pharmacopoeial limits. In-vitro studies revealed that tablets formulation with the high concentration of HPMC (300 mg) and low Concentration of Ethyl Cellulose (100mg) showed desired release of drug in colonic environment. Combination of retardants shows greater retarding of drug release. The compatibility of the drug and polymer were determined by FTIR spectroscopy. Results showed that the drug was compatible with all polymers.

Keywords: Colon Targeting, Lornoxicam, HPMC, Ethyl cellulose, FTIR, Sustained Release.